"Irony" of managing refractory anemia with transfusional support in hemophagocytic lymphohistiocytosis.
| Publication Type | Case Report |
| Authors | Lee S, Salehi I, Chary M, Schiano T, Mascarenhas J |
| Journal | Transfus Apher Sci |
| Volume | 55 |
| Issue | 1 |
| Pagination | 105-8 |
| Date Published | 04/05/2016 |
| ISSN | 1473-0502 |
| Keywords | Anemia, Refractory, Erythrocyte Transfusion, Iron Overload, Lymphohistiocytosis, Hemophagocytic |
| Abstract | Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening derangement of the immune system in which host macrophages phagocytose the patient's own blood cells. Herein, we present the case of a patient with HLH and associated refractory anemia who developed rapid iron deposition in the liver after transfusion of sixteen units of packed red blood cells (RBCs). Before transfusion, neither a liver biopsy nor computed tomography scan demonstrated iron deposition in the organ parenchyma. After receiving sixteen units of packed RBCs, liver iron concentration rose to 6.7 mg/g dry weight, which is highly unusual in other diseases requiring transfusional support. |
| DOI | 10.1016/j.transci.2016.03.007 |
| PubMed ID | 27102761 |